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KMID : 0854720120320010026
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Korean Journal of Asthma, Allergy and Clinical Immunology
2012 Volume.32 No. 1 p.26 ~ p.33
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The Effect of the Mixed Herbal Extract Lotion for Korean Patient with Atopic Dermatitis; A Pilot Study
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Son In-Pyeong
Lim Yun-Young
Kim Hyeong-Mi
Kim Min-Young
Suk Jang-Mi
Kim Young-Heui
Kim Ki-Ho
Kim Beom-Joon
Kim Myeung-Nam
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Abstract
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Background:The choice of topical agents is very important for patients with atopic dermatitis (AD) because mild to
moderate AD-related symptoms and skin lesions could be significantly relieved with appropriate topical treatment. This
study was performed to evaluate the effectineness of a mixed herbal extract lotion containing the extract of Sophorae Radix, Cinnamomi Cortex, Saururi Herba Seu Rhizoma and Aurantii Immaturus Fructus in relieving symptoms and skin lesions associated with AD.
Methods:A total of 24 patients who were suffering mildto moderate AD applied topical lotions, i.e. the test lotion
on the right antecubital fossa and the control lotion on the left antecubital fossa twice daily for up to 4 weeks. The treatment efficacy was evaluated by the measurement of skin hydration and trans-epidermal water loss (TEWL) on the same site at each visit. Additional evaluation methods were the investigator global assessment (IGA) and the visual analogue scale visual analogue scale for pruritus.
Results:The test lotion-applied right antecubital fossa achieved more clinical improvement than the control lotion-applied left antecubital fossa. TEWL on the test side more significantly decreased than that on the control side after4
weeks of lotion application. There were slightly more improvements in both the IGA and patient assessment of pruritus on the test side.
Conslusion:Mixed herbal extract lotions containing the extracts of Sophorae Radix, Cinnamomi Cortex, Saururi Herba Seu Rhizoma and Aurantii Immaturus Fructus can relieve symptoms, such as pruritus, in AD patients.
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KEYWORD
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Atopic dermatitis, Sophorae Radix, Cinnamomi Cortex, Saururi Herba Seu Rhizoma, Aurantii Immaturus Fructus
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